- Title
- Complicated intra-abdominal infections worldwide: The definitive data of the CIAOW Study
- Creator
- Sartelli, Massimo; Catena, Fausto; Leppaniemi, Ari; Biffl, Walter; Balogh, Zsolt; Bendinelli, Cino; Gupta, Sanjay; Kluger, Yoram; Agresta, Ferdinando; Di Saverio, Salomone; Tugnoli, Gregorio; Jovine, Elio; Ansaloni, Luca; Ordonez, Carlos A.; Whelan, James F.; Fraga, Gustavo P.; Gomes, Carlos Augusto; Pereira Junior, Gerson Alves; Yuan, Kuo-Ching; Bala, Miklosh; Peev, Miroslav P.; Ben-Ishay, Offir; Cui, Yunfeng; Coccolini, Federico; Marwah, Sanjay; Zachariah, Sanoop; Wani, Imtiaz; Rangarajan, Muthukumaran; Sakakushev, Boris; Kong, Victor; Ahmed, Adamu; Abbas, Ashraf; Gonsaga, Ricardo Alessandro Teixeira; Guercioni, Gianluca; Corbella, Davide; Vettoretto, Nereo; Poiasina, Elia; Díaz-Nieto, Rafael; Massalou, Damien; Skrovina, Matej; Gerych, Ihor; Augustin, Goran; Kenig, Jakub; Khokha, Vladimir; Tranà, Cristian; Moore, Ernest E.; Kok, Kenneth Yuh Yen; Mefire, Alain Chichom; Lee, Jae Gil; Hong, Suk-Kyung; Lohse, Helmut Alfredo Segovia; Ghnnam, Wagih; Verni, Alfredo; Lohsiriwat, Varut; Siribumrungwong, Boonying; El Zalabany, Tamer; Malangoni, Mark; Tavares, Alberto; Baiocchi, Gianluca; Das, Koray; Jarry, Julien; Zida, Maurice; Sato, Norio; Murata, Kiyoshi; Shoko, Tomohisa; Irahara, Takayuki; Hamedelneel, Ahmed O.; Velmahos, George; Naidoo, Noel; Adesunkanmi, Abdul Rashid Kayode; Kobe, Yoshiro; Ishii, Waturu; Oka, Kazuyuki; Izawa, Yoshitmitsu; Hamid, Hytham; Khan, Iqbal; Attri, A. K.; Sharma, Rajeev; Coimbra, Raul; Sanjuan, Juan; Badiel, Marisol; Barnabé, Rita; Koike, Kaoru
- Relation
- World Journal of Emergency Surgery Vol. 9
- Publisher Link
- http://dx.doi.org/10.1186/1749-7922-9-37
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2014
- Description
- The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).
- Subject
- intra-abdominal infections; pathalogical conditions; source control; antimicrobial therapy
- Identifier
- http://hdl.handle.net/1959.13/1060478
- Identifier
- uon:16782
- Identifier
- ISSN:1749-7922
- Language
- eng
- Full Text
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